Carteolol is a partial agonist on β2-adrenoceptors and atypical 0-adrenoceptors in guinea pig gastrointestine
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منابع مشابه
In Vitro Evidence That Carteolol Is a Nonconventional Partial Agonist of Guinea Pig Cardiac 1-Adrenoceptors: A Comparison with Xamoterol
The present study was designed to verify our previous hypothesis that carteolol, a 1/ 2-adrenoceptor-blocking agent, is a nonconventional partial agonist of cardiac 1-adrenoceptors. To this purpose, we characterized the effects of carteolol in guinea pig myocardial preparations and measured the affinities of carteolol for highand low-affinity sites of 1-adrenoceptors labeled by CGP12177 [( )4-(...
متن کاملIn vitro evidence that carteolol is a nonconventional partial agonist of guinea pig cardiac beta1-adrenoceptors: a comparison with xamoterol.
The present study was designed to verify our previous hypothesis that carteolol, a beta1/beta2-adrenoceptor-blocking agent, is a nonconventional partial agonist of cardiac beta1-adrenoceptors. To this purpose, we characterized the effects of carteolol in guinea pig myocardial preparations and measured the affinities of carteolol for high- and low-affinity sites of beta1-adrenoceptors labeled by...
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The β2-adrenergic effects of macerated extract, aqueous extract, ethanol extract, and essential oil of Carum copticum, 5 nM propranolol, and saline were tested by performing cumulative Log concentration-response curves of isoprenaline-induced relaxation of precontracted isolated guinea pig tracheal chains in three different conditions including: non-incubated (group 1, n=9) incubated with 1...
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Using electrical field stimulation of epithelium-denuded intact guinea pig tracheal tube preparations, we studied the presence and role of prejunctional β2-adrenoceptors by measuring evoked endogenous acetylcholine (ACh) and norepinephrine (NE) release directly. Analysis of ACh and NE was through two HPLC systems with electrochemical detection. Electrical field stimulation (150 mA, 0.8 ms, 16 H...
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Our previous studies have demonstrated the relaxant, anticholinergic (functional antagonism), antihistaminic, and inhibitory effect of calcium channels of Nigella sativa on guinea pig tracheal chains. To investigate the other mechanism responsible for the relaxant effect of this plant, the stimulatory effect of Nigella sativa on ß 2 -adrenergic receptors in tracheal chains of the guinea pig was...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 2000
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)47865-7